Science and technology play a key role in economic development; and Universities have a direct stake in this process. A knowledge-based economy requires scientific and technological expertise that is strongly influenced by the strength of training in science and technology. However, in Uganda not many students opt for science subject at higher levels, and subsequently in the University. Therefore, there is need to encourage and motivate students to study science subjects in order for this to be successful. This can be achieved through introduction of stimulating subjects such as astronomy in the university curriculum. This is because astronomy is considered as one of the most appealing subject and an excellent tool for conveying scientific knowledge to young students. The role that astronomy has played to motivate and interest students to study physics in Mbarara University of Science and Technology in particular, and in Uganda general, will be discussed.